
- Salmon-Derived Polynucleotides – Obtained from salmon sperm DNA and designed to improve the appearance of skin texture, elasticity and overall skin quality.
- Targets Fine Lines and Skin Concerns – May help improve the appearance of fine lines and skin that appears thin or crepey.
- Personalised Treatment Planning – Treatment areas and session recommendations are tailored to your skin concerns and clinical assessment.
Rejuran is a polynucleotide-based injectable treatment derived from purified DNA fragments sourced from salmon. Often referred to as “salmon DNA” treatment, Rejuran is designed to support the skin’s natural repair processes and improve skin quality, texture and elasticity.
At Medaesthetics, we assess your skin concerns and treatment goals to determine whether Rejuran is suitable for your individual needs.
Rejuran Treatment Highlights
Treatment Discomfort:
We use extra-strength topical numbing cream to minimise any treatment discomfort
Longevity:
Results last for upto 12 months. Individual results vary.
Location:
Available at all MedAesthetics clinics.
Rejuran Treatment Cost
from $750
Costs are confirmed at your consultation. Pricing is for general guidelines only and may vary based upon the individual clinical requirements.
Rejuran Procedure Information
Treatment Areas
- Face
- Upper and lower eyelid skin
- Peri-oral lines (lines around the mouth)
- Neck
- Hands
- Décolletage
Common Names
- Rejuran
- Polynucleotide (PN) skin treatment
- Salmon-DNA polynucleotide treatment
- Salmon Sperm Treatment
MOA
Rejuran contains polynucleotides (PN) derived from purified salmon DNA. When injected into the skin, these molecules are intended to support tissue repair processes and improve the skin’s overall quality. Polynucleotides may help support fibroblast activity and extracellular matrix remodelling, contributing to improvements in skin texture, elasticity and hydration over time. Results develop gradually and vary between individuals.
Rejuran Treatment Summary
Number of Treatments
An initial course of 2–3 treatment sessions, typically spaced 3–4 weeks apart, may be recommended depending on your skin concerns and treatment response. Maintenance treatments may be considered to help sustain improvements over time.
Procedure Time
Each session takes around 15 minutes, plus time for the numbing cream to take effect.
Discomfort Level
Discomfort is usually mild once the area is numbed with a high-strength topical numbing cream, though sensation varies between individuals.
Recovery Time
Expect around 24–48 hours of possible redness, swelling or bruising at the injection sites, which generally settles within a few days.
Results
Results develop gradually — most people notice a change within about 2–4 weeks, with the fuller effect after completing the recommended course. Results vary between individuals and are not guaranteed.
Duration of Results
Results are generally reported to last around 8 to 12 months and varies between individuals. Maintenance treatments once or twice a year are recommended for long term benefits.
Resumption of Usual Activities
Most people resume usual activities soon after treatment, avoiding strenuous activity and heat exposure for 48 hours.
Aftercare
Aftercare advice includes avoiding strenuous activity, direct sun or heat exposure for 72 hours.
Rejuran General Information
Process
- Consultation and Assessment – We assess your skin concerns, medical history and suitability for Rejuran treatment, discussing expected outcomes, potential risks and alternatives.
- Clinical Photography and Consent – Clinical photographs may be taken before treatment, with your informed consent, to document your baseline skin condition and monitor progress.
- Skin Preparation – The treatment area is cleansed, and a topical anaesthetic may be applied to improve comfort.
- Treatment Administration – Rejuran is administered through a series of small injections into the targeted areas of the skin, using a technique tailored to your treatment plan.
- Post-Treatment Assessment – We assess the skin following treatment and provide personalised aftercare instructions.
- Follow-Up – Further sessions may be recommended according to your skin concerns and response. Follow-up clinical photographs may be taken with your informed consent to document changes over time.
How to Choose Your Rejuran Treatment Provider?
Choose a qualified and experienced medical practitioner who understands skin anatomy, injectable treatments and the potential risks associated with polynucleotide-based products. Your provider should conduct a thorough assessment, explain expected outcomes and limitations, and provide clear aftercare guidance.
At Medaesthetics, we prioritise individual assessment, personalised treatment planning and patient safety. We discuss the potential benefits, risks and alternatives before proceeding, and clinical photographs are taken only with your informed consent to help document treatment progress.
Why Choose MedAesthetics for Rejuran?
At Medaesthetics, we take a clinically guided approach to Rejuran treatment, with a focus on individual assessment, appropriate treatment planning and patient safety.
- Experienced Clinical Team – Clinical experience in cosmetic medicine and skin rejuvenation.
- Personalised Treatment Planning – Treatment recommendations tailored to your skin concerns, condition and goals.
- Evidence-Informed Approach – We discuss the potential benefits, limitations and risks of polynucleotide treatments to support informed decision-making.
- Patient-Focused Care – Clear guidance on treatment expectations, recovery and aftercare.
- Ongoing Assessment – We monitor your response to treatment, with clinical photography undertaken only with your informed consent.
All cosmetic procedures carry risks. These include: swelling, bruising, infection, allergic reaction, asymmetrical results, vascular injury, nerve trauma, visual disturbances, psychological trauma and grievous body harm. For more information, please visit our website and find the link to the “Risks & Complications” page at the bottom of our website home page on medaesthetics.com.au. Before/After images are of actual DermAesthetics/Medaesthetics patients as well as stock images provided by the medical product suppliers. These images are for reference purposes only. Individual results may vary. Please obtain expert opinion from at least two different medical providers before undergoing any cosmetic treatment.
For additional information on potential risks please click here.
Frequently asked questions
What is Rejuran?
Rejuran is an injectable skin treatment that uses polynucleotides derived from salmon DNA to support the skin’s natural repair processes, collagen production and texture. It is regulated as a medical device.
How does it work?
Polynucleotides are injected into the dermis using fine needles. They are intended to support the skin’s natural regenerative processes; individual responses vary.
How many sessions will I need?
A course of 3–4 sessions about 4 weeks apart is typically recommended, with maintenance every 6–12 months. Your clinician will advise after assessing your skin.
When will I see results?
Most people notice a gradual change within about 2–4 weeks, with the fuller effect after completing the recommended course. Results vary between individuals,
Are there side effects?
Common, temporary effects include redness, swelling and bruising at the injection sites. Less commonly, an allergic reaction or treatment resistance can occur. Full risk information is discussed at consultation.
Who is not suitable for Rejuran?
It is generally not suitable for people with known seafood allergies, vegans and vegetarians, people with an auto-immune disorder, or during pregnancy. Suitability is confirmed at consultation.
Can Rejuran be combined with other treatments?
It can be considered alongside other skin treatments such as lasers, PRP and chemical peels. Your clinician will advise what is appropriate for you.
Our team
The clinical team at MedAesthetics is at the forefront of addressing the entire spectrum of cosmetic facial rejuvenation, anti-ageing, hair restoration, laser and cosmetic surgery.

Medical Practitioner – Registration Type: General

Dermal Clinician

Registered Cosmetic Nurse

Registered Cosmetic Nurse

Registered Cosmetic Nurse

Registered Practice Nurse

Registered Cosmetic Nurse

Registered Cosmetic Nurse

Registered Cosmetic Nurse

Dermal Clinician

Dermal Clinician

Dermal Clinician

Registered Cosmetic Nurse

Dermal Clinician

Registered Cosmetic Nurse

Dermal Clinician

Registered Cosmetic Nurse
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Prefer to talk? Call 08 9381 5840.
